Drug Delivery
Phosphagenics has focused its pharmaceutical research efforts towards maximizing the development of its patented drug delivery technology TPM.
The potential benefits of transdermal drug delivery have been widely reported in scientific literature and include a reduction in dose related side effects, the prevention of first-pass hepatic elimination and gastrointestinal degradation, as well as improved patient compliance.
TPM delivery systems are suitable for delivery of both small and large molecules (e.g. peptides).
TPM delivery systems include:
1. Vesicular systems
2. Micro-emulsions
3. Liquids
4. Patch systems (reservoir and thin film matrix)
The key distinguishing features that contribute to the uniqueness and advantages of both the delivery system, and the benefits they provide with respect to transdermal delivery are summarised below.
Key Features and Benefits of TPM in transdermal delivery
|
|
Feature
|
Benefits
|
| 1 |
Can transport both small and large molecules |
Technology applicable to a wide range of drugs |
| 2 |
Powerful penetration enhancers that do not disrupt or irritate the dermis |
- No skin irritation
- Maintains skin integrity |
| 3 |
Allow for a sustained release of compounds from just one application |
- Flexible dosage regimens
- Longer therapeutic levels maintained |
| 4 |
Rapidly penetrate the dermis (less than 1 hour) |
- Permits normal daily activities (e.g. showers, swimming) |
| 5 |
Cost-effective to produce |
- Significant value add opportunity |
| 6 |
Other routes of administration beyond transdermal under investigation |
- Can be produced in wide range of presentations (powder, liquid, gel, sprays etc) |