Diclofenac

Diclofenac is a leading non steroidal anti-inflammatory drug (NSAID) widely used for sprains and strains and is commonly marketed as Voltaren®. Voltaren® is expected to acheive global sales revenues of USD 819 million in 2010 for both oral and topical applications with a year-on-year growth rate of 9% from 2009.

Phosphagenics’ TPM™ pharmaceutical delivery technology can be used as a targeted, localised delivery system, to increase the delivery of actives such as diclofenac to targeted areas, while minimising exposure to the rest of the body.

A Phase IB human study was completed in 2009 and demonstrated that Phosphagenics’ TPM/diclofenac formulation results in more effective permeatiation of diclofenac into the skin than the currently available Voltaren® gel. The study showed that dermal absorption of diclofenac was increased compared with Voltaren® gel, while maintaining similar levels of systemic exposure.