Lidocaine

Lidocaine is a well known topical local anaesthetic used for a wide variety of ailments, including temporary relief of rashes, stings, sprains, strains, bites, and burns. However it has poor penetration into the dermis, frequently rendering it largely ineffective. Global sales of topical local anesthetics in 2007 were US$ 1.2 billion.

Lidocaine is sold in many forms, it is available as an ointment, jelly, patch, or aerosol for topical use, as an oral solution, and as an injection for local anesthesia.

Phosphagenics’ drug delivery technology has the ability to be used as a targeted, localised delivery system, capable of increasing the delivery of actives such as lidocaine, to targeted areas while minimising exposure to the rest of the body.

Phosphagenics’ transdermal lidocaine is capable of improving the penetration rate and delivery concentration of lidocaine, while importantly, limiting systemic exposure.

Phosphagenics’ transdermal lidocaine successfully completed a phase 1 human clinical trial in 2008. This trial demonstrated that Phosphagenics’ patented delivery system is able to increase both the depth of delivery of Lidocaine and the amount of Lidocaine delivered into skin compared to a leading marketed preparation.