Phosphagenics - pharms delivery

Overview

Drug Delivery

-	TPM-01
-	TPM-02

Drug Enhancement

-	APA-01
-	GTP-0805

R&D Pipeline

TPM-02 delivery system

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Drug Delivery

Phosphagenics has focused its pharmaceutical research efforts towards maximizing the development of its patented transdermal delivery technology TPM. As a result of recent significant successes in this area, and initial in-vitro research, it is now planned to expand this development by exploring the application of our platform in delivering drugs both orally and via the pulmonary route.

The potential benefits of transdermal drug delivery have been widely reported in scientific literature and include a reduction in dose related side effects, the prevention of first-pass hepatic elimination and gastrointestinal degradation, as well as improved patient compliance.

Phosphagenics currently has two pharmaceutical grade transdermal delivery systems under development:

· TPM-01, for delivery of small molecules

· TPM-02, for delivery of both small and large molecules (e.g. peptides)

The key distinguishing features that contribute to the uniqueness and advantages of both these delivery systems, and the benefits they provide with respect to transdermal delivery are summarised below.

Key Features and Benefits of TPM-01 and TPM-02 in transdermal delivery
	Feature	Benefits

1	Can transport both small and large molecules	- Technology applicable to a wide range of drugs

2	Powerful penetration enhancers that do not disrupt or irritate the dermis	- No skin irritation - Maintains skin integrity

3	Allow for a sustained release of compounds from just one application	- Flexible dosage regimens - Longer therapeutic levels maintained

4	Rapidly penetrate the dermis (less than 1 hour)	- Permits normal daily activities (e.g. showers, swimming)

5	Cost-effective to produce	- Significant value add opportunity

6	Other routes of administration beyond transdermal under investigation	- Can be produced in wide range of presentations (powder, liquid, gel etc)

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