Phosphagenics’ TPM® technology is used in a number of high-quality body care and skin care products throughout the world. Our consumer health products, based on over 10 years of scientific research and development, offer innovative solutions for modern women who want personal care products that actually work. Our strategy for developing products is simple: we select the most powerful active ingredients available to the skin care industry, and then deliver them into the skin to where they are needed most with our patented TPM® Delivery Technology. Our scientists have developed a range of breakthrough anti-aging, anti-cellulite, anti-stretch mark products that are reinventing what is possible in the consumer health industry.

Unlike most other personal care products, which sit on the surface of the skin, scientific testing shows that TPM® Delivery Technology absorbs further into the skin. Vitamin E in Phosphagenics’ skin care products is in the form of tocopheryl phosphate, while Vitamin E in other brands’ skin care products is in the form of tocopheryl acetate. Figure 1 shows that the TPM® absorbs up to 4x greater than tocopheryl acetate into the epidermis, and up to 9x greater into the dermis. What this means is that TPM® enhances the delivery of active cosmetic ingredients into the skin. The result is that key ingredients in each TPM® based product are delivered deeper into the skin’s layers, where they are needed most, resulting in smoother, firmer, younger looking skin. Figure 2 shows results comparing the absorption of key skin care ingredients in formulations with TPM® and without TPM® (Franz Cell in vitro testing on human skin):

Vitamin E in TPM® Products
  • 49%left on top
    of the skin
  • 24%reaches the
  • 4x greater absorption
  • 27%reaches the
  • 9x greater absorption

Vitamin E Acetate vs. Vitamin E Phosphate - Skin Absorption

Vitamin E in Other Brands
  • 91%left on top
    of the skin
  • 6%reaches the
  • 3%reaches the
Active Ingredient Benefit to the Skin Absorption Into the Skin
Vitamin A Retinol is an antioxidant that increases collagen production and enhances the skin’s barrier function.
4xmoreVitamin A
CoEnzyme Q10 An antioxidant that occurs naturally in the body and helps to protect cells from free radical damage.
4xmoreCoEnzyme Q10
Carnosine A potent, naturally occurring anti-aging antioxidant that inhibits AGEs and the cross linking of collagen.
Caffeine Well known natural ingredient that inhibits ‘bad fat’ deposition in fat cells and limits storage of fat in cells.
Forskolin Belongs to the mint and lavender plan family. It is a signaling molecule that stimulates lipolysis and counteracts the decreased response of fat cells associated with aging.
  • without TPM®
  • with TPM®
Le Métier de Beauté – Licensing

Le Métier de Beauté – Licensing
Phosphagenics has licensed the use of TPM® in skin care products to Le Métier de Beauté (LMDB), a prestige skin care brand based in New York. LMDB promotes the benefits of our TPM® Delivery Technology as a premium delivery system plus uses Vital ET® as a key cosmetic ingredient. Le Metier’s range of skin care products containing TPM® and Vital ET® can be found in prestigious US department stores such as Bergdorf Goodman, Neiman Marcus and Nordstrom, as well as recent distribution through QVC. Phosphagenics has granted LMDB a non-exclusive license, and in turn receives a royalty on net sales of TPM® containing products, in addition to supplying TPM®.

Ashland – Raw Ingredients

Phosphagenics’ first major commercial agreement for the supply of raw ingredients (Vital ET®) was with Ashland Inc. (formerly ISP). The collaboration was established in 2003, and is still active. Under this arrangement, Phosphagenics manufactures Vital ET® at our manufacturing plant in Australia, while Ashland distributes the product into the North American, European, Asian and South American markets. Although it has many other applications, Vital ET® is primarily promoted as a biofunctional ingredient used in the pre-treatment / skin health phase for products targeted at Acne resolution.

Vital ET® is a natural form of stable Vitamin E comprising Tocopheryl Phosphate (a natural Phosphorylated form of Vitamin E) and Disodium Lauryliminodipropionate (a complexing agent) which has been shown to deliver more Vitamin E into human skin when compared to the form of Vitamin E commonly used in the skincare industry (tocopheryl acetate). Vital ET® takes Vitamin E one step further to make it more stable and more bioavailable resulting in a synergistic approach to adding actives to skincare (due to further absorption into the skin) as well as maximising the effect of the properties of standard Vitamin E.

Vital ET® has been clinically proven to reduce sensitive skin problems including (UV induced redness/sunburn folliculitis, tactile roughness, razor burn, skin clarity and the redness and shape of spots caused by acne)* Making it a very beneficial multifunctional skincare ingredient.

* Clinical Studies performed by ISP group © International Specialty Products.